Antioxidant Protects Islet Cells Used in Transpla
Tuesday, June 10th, 2003July 30, 2002, Acurian
Source: National Jewish Medical and Research Center
A synthetic antioxidant developed by researchers at National Jewish
Medical and Research Center improves the survival of islet cells used
in transplants for diabetes. The findings, reported in the August
2002 issue of the journal Diabetes by researchers at the University
of Pittsburgh, could help overcome a significant drawback of
the “Edmonton Protocol,” a promising treatment for diabetes.
“The antioxidant neutralizes the harmful free radicals generated when
islet cells are isolated from the pancreas,” said senior author Jon
Piganelli, Ph.D., assistant professor of Pediatrics at the Diabetes
Institute, Children’s Hospital of Pittsburgh, and the University of
Pittsburgh School of Medicine. “More of the islet cells survived in
culture. And when we transplanted islet cells into diabetic,
immunodeficient mice, it took fewer of the antioxidant-treated islet
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